Knowledge - Base

A new breed of injectable HA Filler

REMEDIUM HA FILLERS

Innovative Multi - Staged Cross - Linking Technology
LONG
LASTING
SAFE &
REMOVABLE
An elaborate product with high viscosity and cohesiveness through its high cross linking rate, and a
very low particle size to provide moldability, longevity and share maintenance after procedure
REMEDIUM
A new breed of injectable HA Filler
GENERAL OVERVIEW

HYALURONIC ACID s a substance that is naturally present in the human body thatmeans they are extremely safe to use.

People take hyaluronic acid for various joint disorders, including osteoarthritis and joint pain, as well as, HA was approved to be used during certain eye surgeries including cataract removal, corneal transplantation, and repair of a detached retina and other eye injuries.
But honestly saying, Hyaluronic acid is a largerly and recognizedly used in cosmetic surgery. Some people apply hyaluronic acid to the skin for healing wounds, burns, skin ulcers, and as a moisturizer.
There is also a lot of interest in using hyaluronic acid to prevent the effects of aging. In fact, hyaluronic acid has been promoted as a “FOUNTAIN OF YOUTH.”

Highest Rated Medical & Cosmetic Products
Manufacturer in Korea

FOREVER18 International Established in 2016 and imports, exports, and manufactures the leading trends in skincare and medical products with quality-oriented. We also made continuous efforts to developing and searching new and innovative items to introduce to the market as a leader which we aim for.

FOREVER18 International Co. Ltd also assists clients based on trust, reliability, integrity, and commitment for maintaining a long-term relationships.

INNOVATIVE TECHNOLOGY
Multi-stage Cross-Linking Technology

ReMedium introduces a series of hyaluronic acid (HA) fillers from the South Korean company BioPlus Co., Ltd.

ReMedium presents a new generation of hyaluronic acid (HA) fillers for long-lasting aesthetic results. The patented “Multi-stage Cross-Linking (MCL)” technology allows the HA crosslinking speed to be adjusted. The
innovative 3-step processing technology produces ultrafine HA microgranules of three different sizes that are placed one inside the other. Such a complicated structure guarantees an extended duration of the effect compared to
HA fillers obtained by standard cross-linking techniques.

Totally Safe Double Sterilization Technique

100% Animal Free

ReMedium products are produced by highpurity HA raw materials. The products: Nonanimal Bio fermentation Source; No pretreatment skin test required; No risk of transmitting animal diseases.
Double Sterilization such as Aseptic Filling and Terminal Sterilization Stages are applied during the manfacuring process.

MDM patented technology

o MBMT (Micro Bead Monophasic Technology)
– Enable the world’s largest Viscoelasticity by microbeading of the HA (Hyaluronic Acid) and maintaining Monophasic properties.
o DMCT (Divinyl sulfone Multi-
Crosslink Technology)
– Multi-crosslinking of HA with DVS crosslinking agent. A technology to implement complete crosslinking.
o MDAP (Multiple Degree Amphiphilic Purification)
– Technology that improves safety and produces the highest purity products by
refining crosslinked microbeads in multiple times.

CERTIFICATES
ReMedium hyaluronic acid is CE and CPNP certified, as well as, KFDA and GMP certified by the Korea Republic, and has ISO, which all these certificates and licenses guaranty safety and quality.
HYALURONIC ACID FILLERS
Overview

ReMedium products are sterile devices composed of Micro Beads of Cross-linked molecules ofhyaluronic acid gel. Micro Beads of Cross-linked molecules of hyaluronic acid gel is processedfrom non Cross-linked hyaluronic acid supplied from Japan company . Hyaluronic acid hasgood biocompatibility and affinity for water molecules, but it is a soluble polymer that israpidly removed when injected into normal skin. Therefore, the cross-linked hyaluronic acidgel degrades completely over time and is absorbed by the body.

Divinyl Sulfone (DVS) Technique

ReMedium Products are manufactured based on the Divinyl Sulfone (DVS) Technique. AsDVS is a smaller molecule than the normal cross-linker, BDDE (butanediol diglycidyl ether), itsuse ensures that the open hyaluronic acid chains are closed creating a shorter reticulum thatproduces a more compact hyaluronic acid. This also makes it more elastic as it has a greatercapacity to absorb pressure and tension without breaking than the hyaluronic acidsmanufactured with BDDE. A number of experimental studies have shown that the polymerformed with DVS is highly stable, resulting in much more durable cross-linking.

Test for Hydrophilicity

High moisture content means that even a small amountcauses a large amount of effect. By realizing highviscosity with TSC (Third Step Cross linking) technology
,particle structure is dense and it has high moisturecontent

Expected results:
1 Show higher volumetric effect in same filler amount
2 Excellent volume up effect with less capacity
3 Easy molding

Centrifuge test proceeded at a rate of 3,000rpm for 30 minutes. 1 cc of each sample isinjected to 500 cc of moisture

Test for Safety

In general, Hyaluronic acid tends to undergo chemical transformation easily at high crosslinking rate. However, ReMedium, our product proves that in the refractive indexcomparative experiment, the same wavelength pattern maintains as the raw material initiallyhas in spite of higher cross linking rate. It shows 100% of HA maintains without any changes.In other words, there is no harmful effect even if the body absorbs it, both of raw material and
the finished product are 100% of hyaluronic.

HYALURONIC ACID FACE FILLERS
Description

HA Acid Face Fillers are elaborate products with high viscosity and cohesiveness through itshigh cross-linking rate, and a very low particle size to provide
moldability, longevity andshape maintenance after the procedure. The product is safe with no chemical modifications inthe HA, even after a high cross-linking process. The Product provides excellent volume effectthrough its high hydrophilic capacity and stable molecular structure even after high cross-linkage rate.

Expected effects

Correction of wrinkles, folds and scars, making lips more sensual and voluminous, sculptingand shaping the contours of the face, hydrating, plumping and rejuvenating the skin,improving the tone and elasticity of the skin.

Test for Safety

Sub-q is the hardest gel in its product line. Smaller particle size allows easymodeling that can be used on any part of the face to increase volume and improvethe contours.
Application area : forehead, nose, cheeks, folds, lips, chin and to improve deepwrinkles such as nasolabial wrinkles

Lasting : 12 ~ 18 month

Elasticity modulus : 80~130

Particle Size : 450μm

Mid is with medium particle size for moderate wrinkles. Injected in the middle partof dermis.

Application area: Nasolabial folds, forehead wrinkles, brow wrinkles, mouthwrinkles, marionette wrinkles, lips

Lasting : 9 ~ 12 months

Elasticity modulus : 50-80

Particle Size : 350μm

Fine is less hard and has a smaller particle size. Effectively improves very thinsuperficial lines. Injected in the upper part of the dermis.

Application area : Face, neck, neckline area, back of the hand, fine wrinkles,marionette wrinkles, wrinkles around the mouth, nasolacrimal furrows, horizontalwrinkles on the forehead, forehead wrinkles.

Lasting : 6 ~ 9 months

Elasticity modulus : 30-50

Particle Size : 200μm

SKIN BOOSTER - REMEDIUM AQUA
Sodium Hyaluronate - Sterile Pre-filled
Description

The Aquashine procedure is one of the ways to rejuvenate the skin with the help of a uniform and direct injection of hyaluronic
acid into the dermis layer, which leads to the brightness and moistening of the skin, concentrating the moisture, since the HA has a moistening effect.

Sterile gel preparation based on unstabilized hyaluronic acid “Shiseido” in the
concentration of 10mg/ml, it is injected as Mesotherapy.

ReMedium Aqua injection can help plump up the skin, protect them from the harmful effects of free radicals, improve blood microculation, and normalize the complexion.

Area of use

Forehead, Eyebrows, around eyes, nasolabial wrinkles, chin and breast, hand back, neck and neckline, all face

Effect of the Procedure
  • SKIN REJUVENATION

Brightens the skin, imporves the texture of the skin and elasticity of the skin, pulls up the pins, removes pigments such as freckles and spots, highlights make up.

  • AGAINST AGING

Removes fine wrinkles andprevents aging of the skin

  • HUMIDIFICATION

Improves the condition of the skin regardless of the seasons, removes dead skin cells.

Injection Technique

The Drug is injected at a depth of 1mm into the surface layers of the epidermis. The skin should be anesthetized, then ReMedium Aqua should be injected with a needle or an injection device evenly, if necessary other care products also can be applied. Avoid touching, massage, sauna and extreme workout and sunlight.

Injection Interval

o 1st Stage:
Inject first 2 treatments by every 3-4 weeks

o 2nd Stage:
Inject every 3 months after 1st stage

Lasting and Appeared Effect

o Appeared effect is visible after 1-2 weeks
o Product’s effect lasts for 3-4 months.

Packaging Info

o Non Cross linked Hyaluronic acid 20mg/ml
o ReMedium Aqua 2ea x 2ml
o 2 prefilled syringe / 1 boxo
o The Product is 4 ml in total

REMEDIUM HA FILLERS TYPES
Indications and selection of types
HYALURONIC ACID BODY FILLERS

The Product increases long-lasting effect in the human body, increases fullness and projection of our breasts and upper buttocks and improves the balance of our figure. The product has strong viscosity, gel hardness and easy molding characteristics. High viscosity is obtained through patented stage micro beads manufacturing technology based on cross linked Hyaluronic Acid.

An elaborate product with high viscosity and cohesiveness through its high cross-linking rate, and a very low particle size to provide moldability, longevity and shape maintenance after the procedure. The product is safe with no chemical modifications in the HA, even after a high cross-linking process.

REMEDIUM ADVANCE -S
Upper Breast Side
Increases fullness and projection of Breast and impoves the balance of the figure.
REMEDIUM ADVANCE -H

Upper Buttocks Side
Increases fullness and projection of Upper Buttocks and impoves the balance of
the figure.

TEST FOR VISCOSITY & MOLDING

Results of measuring the sliding down of ReMedium products compared with other brands’ products. After 4 minutes elapse as shown below, white third-party products slammed down a lot, OUR PRODUCTS CAN BE SEEN TO KEEP SHAPES ON AN ONGOING BASIS.

MESO THREADS
PDO suture therapy effects

It has qualified clinically to wound closure, can lift up skin tissue and regenerate the skin. improves skin tone and minimizing pores, has strong effect on making a face contouring, arranging protruding area and lifting for sagging area.

Area of Use

Around cheeks, forehead (eyebrow lifting), jawline, sunken cheeks, crow’s feet, neck, nasolabial fold, marionette line

Regarding Lasting

The suture is absorbing within 6-8 months, whose effect lasts for 3 years

ReMedium Vline Types

CAVERN /MOLDING COG/ MULTI THREAD/ DOUBLE / SCREW/ DOUBLE NEEDLE WITH CAVERN / I-CAVERN/  COGSCREW / COG / MONO / CLEOKO /
DOUBLE NEEDLE / TAPS KO TANXING CAVERN / F-CAVERN

Injection Procedure

Inject local anesthesia and insert PDO Suture with the needle (cannula). This
Procedure by PDO depends on requirements of clients. It takes 45-60 minutes. Patient can cantinue daily life after treatment.

Warnings and specific precautions
regarding application
Side Effects That Can Occur At The Result Of The Filler Application
  • Redness, pain, tenderness
  • Swelling, bruising, itching, infection
  • Allergic reactions, discharge swelling, sunkenscar
  • Palpable masses, asymmetry, color change feltwhile touching
  • Blood circulatory disorders (ischemia) as a resultof constriction of blood vessels or blockage byfiller particles
  • Skin necrosis
  • Unilateral, bilateral visual impairment or blindness
Side Effects That Can Occur At The Result Of The Filler Application
  • Before coming to the filler application procedure, please come well rested(relaxed) and haled.
  • Do not consume alcoholic beverages before the application.
  • It is not recommended to take blood thinners (aspirin, etc.), high-dose vitamin E, anti-rheumaticnon-steroidal anti-inflammatory drugs, retenoids and hormonal drugs at least two weeks prior tothe filler application procedure.
Rehabilitation period
  • Do not touch the filler applied area
  • Make-up can be applied at least after 24 hours
  • It is advied to avoid intense sports for at least 2 weeks
  • Avoid hot environments such as saunas and jacuzzis for at least 2 weeks
  • In case of lip augmentation, do not consume hot-cold food and drinks for 3 days
  • Do not eat or drink anything until the sensation returns (2-3 hours) as the while lip augmentations the lipis anesthetized
  • Do not massage the application area for at least 1 week.
  • Bruising caused by injection usually lasts 4-10 days, swelling lasts 3-7 days.
  • The settling time of the filler in the filler application area is 2-4 weeks. It is normal to have asymmetryand unevenness during this period.
  • In case of any contraindications not mentioned above, please consult your treating physician.

Information about you (personal information, illness, treatment) will not be disclosed without your consent and court order.You have the right to view and make copies of your own file, but this right does not include the right to look at the files ofthird parties. The side effects that will occur will be evaluated by our doctor and the remediation (prescription, medicalintervention, emergency response) procedures will be done by our doctor.

By signing where my name is written below, I declare that I have read this information and consent form, that my doctor hasgiven me verbal and written information about the procedures to be done in a language that I can understand, that all myquestions have been answered and that I have obtained all the information necessary for me, and that I have given my freeand open will to allow my doctor to Realize the Filler Appliation procedure

FAQs
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Derma Fillers are made from a substance that occurs  naturally in human skin-this means they are extremely safe to use and can give fantastic enhancements to lips and facial lines.

You will see results immediately, however, some swelling and redness is not uncommon and as such, the immedicate result should not be regarded as the final result. Best results are seen after 2-3 days

It is long lasting, but not permanent. Depending on the product used, the injection area treated and the individual dispozitions of your skin, the results can last from 6 months up to 18 months.

You may experience some discomfort such as temporary tenderness, redness, swelling on the injected area. They usually disappear on their own in less than 7 days. You can apply an ice pack for a brief period on the injection site to help ease any swelling.

The injections are done with very fine needles and are usually pain-free. Subject to the treated area and your sensitivity, anesthetic cream or block can be applied before the procedure.

In order to reduce the risk of bruising and bleeding at the injection site, avoid any medications such as anticoagulants and  antiinflammatories, that can
prolong bleeding, the week before receiving the treatment. After the injection, you should not apply any make-up for 12 hours and avoid sunbathing or high temperatures for one week. Ask your healthcare professional what he or she recommends.