Knowledge - Base

A new breed of injectable HA Filler


Innovative Multi - Staged Cross - Linking Technology
An elaborate product with high viscosity and cohesiveness through its high cross linking rate, and a
very low particle size to provide moldability, longevity and share maintenance after procedure

HYALURONIC ACID s a substance that is naturally present in the human body that means they are extremely safe to use.

People take hyaluronic acid for various joint disorders, including osteoarthritis and joint pain, as well as, HA was approved to be used during certain eye surgeries including cataract removal, corneal transplantation, and repair of a detached retina and other eye injuries.
But honestly saying, Hyaluronic acid is a largerly and recognizedly used in cosmetic surgery. Some people apply hyaluronic acid to the skin for healing wounds, burns, skin ulcers, and as a moisturizer.
There is also a lot of interest in using hyaluronic acid to prevent the effects of aging. In fact, hyaluronic acid has been promoted as a “FOUNTAIN OF YOUTH.”

Highest Rated Medical & Cosmetic Products
Manufacturer in Korea

FOREVER18 International Established in 2016 and imports, exports, and manufactures the leading trends in skincare and medical products with quality-oriented. We also made continuous efforts to developing and searching new and innovative items to introduce to the market as a leader which we aim for.

FOREVER18 International Co. Ltd also assists clients based on trust, reliability, integrity, and commitment for maintaining a long-term relationships.

Innovative Technology
Multi-stage Cross-Linking Technology

ReMedium introduces a series of hyaluronic acid (HA) fillers from the South Korean company BioPlus Co., Ltd.

ReMedium presents a new generation of hyaluronic acid (HA) fillers for long-lasting aesthetic results. The patented “Multi-stage Cross-Linking (MCL)” technology allows the HA crosslinking speed to be adjusted. The innovative 3-step processing technology produces ultrafine HA microgranules of three different sizes that are placed one inside the other. Such a complicated structure guarantees an extended duration of the effect compared to HA fillers obtained by standard cross-linking techniques.

Totally Safe Double Sterilization Technique

100% Animal Free

ReMedium products are produced by highpurity HA raw materials.

The products:

  • No nanimal Bio fermentation Source;
  • No pretreatment skin test required;
  • No risk of transmitting animal diseases.

Double Sterilization such as Aseptic Filling and Terminal Sterilization Stages are applied during the manfacuring process.

MDM patented technology
MBMT (Micro Bead Monophasic

Enable the world’s largest Viscoelasticity by microbeading of the HA (Hyaluronic Acid) and maintaining Monophasic properties.

DMCT (Divinyl sulfone Multi- Cross-link Technology)

Multi-cross-linking of HA with DVS cross-linking agent. A technology to implement complete cross-linking.

MDAP (Multiple Degree Amphiphilic Purification)

Technology that improves safety and produces the highest purity products by
refining crosslinked microbeads in multiple times.

ReMedium hyaluronic acid is CE and CPNP certified, as well as, KFDA and GMP certified by the Korea Republic,
and has ISO, which all these certificates and licenses guaranty safety and quality.
Hyaluronic Acid Fillers

ReMedium products are sterile devices composed of Micro Beads of Cross-linked molecules ofhyaluronic acid gel. Micro Beads of Cross-linked molecules of hyaluronic acid gel is processedfrom non Cross-linked hyaluronic acid supplied from Japan company . Hyaluronic acid hasgood biocompatibility and affinity for water molecules, but it is a soluble polymer that israpidly removed when injected into normal skin. Therefore, the cross-linked hyaluronic acidgel degrades completely over time and is absorbed by the body.

Divinyl Sulfone (DVS) Technique

ReMedium Products are manufactured based on the Divinyl Sulfone (DVS) Technique. AsDVS is a smaller molecule than the normal cross-linker, BDDE (butanediol diglycidyl ether), itsuse ensures that the open hyaluronic acid chains are closed creating a shorter reticulum thatproduces a more compact hyaluronic acid. This also makes it more elastic as it has a greatercapacity to absorb pressure and tension without breaking than the hyaluronic acidsmanufactured with BDDE. A number of experimental studies have shown that the polymerformed with DVS is highly stable, resulting in much more durable cross-linking.

Test for Hydrophilicity

High moisture content means that even a small amountcauses a large amount of effect. By realizing highviscosity with TSC (Third Step Cross linking) technology
,particle structure is dense and it has high moisturecontent

Expected results:
1 Show higher volumetric effect in same filler amount.
2 Excellent volume up effect with less capacity.
3 Easy molding.

Centrifuge test proceeded at a rate of
3,000rpm for 30 minutes. 1 cc of each
sample isinjected to 500 cc of
Test of Safety

In general, Hyaluronic acid tends to undergo chemical transformation easily at high cross-linking rate. However, ReMedium, our product proves that in the refractive indexcomparative experiment, the same wavelength pattern maintains as the raw material initiallyhas in spite of higher cross linking rate. It shows 100% of HA maintains without any changes.In other words, there is no harmful effect even if the body absorbs it, both of raw material and the finished product are 100% of hyaluronic.

Hayuluronic Acid Face Filler

HA Acid Face Fillers are elaborate products with high viscosity and cohesiveness through itshigh cross-linking rate, and a very low particle size to provide
moldability, longevity andshape maintenance after the procedure. The product is safe with no chemical modifications inthe HA, even after a high cross-linking process. The Product provides excellent volume effectthrough its high hydrophilic capacity and stable molecular structure even after high cross-linkage rate.

Expected effects

Correction of wrinkles, folds and scars, making lips more sensual and voluminous, sculptingand shaping the contours of the face, hydrating, plumping and rejuvenating the skin,improving the tone and elasticity of the skin.

Application Area

Correction of wrinkles, folds and scars, making lips more sensual and voluminous, sculptingand shaping the contours of the face, hydrating, plumping and rejuvenating the skin,improving the tone and elasticity of the skin.

Sub-q is the hardest gel in its product line. Smaller particle size allows easymodeling that can be used on any part of the face to increase volume and improvethe contours.
Application area : forehead, nose, cheeks, folds, lips, chin and to improve deepwrinkles such as nasolabial wrinkles

Lasting : 12 ~ 18 month

Elasticity modulus : 80~130

Particle Size : 450μm

Mid is with medium particle size for moderate wrinkles. Injected in the middle partof dermis.

Application area: Nasolabial folds, forehead wrinkles, brow wrinkles, mouthwrinkles, marionette wrinkles, lips

Lasting : 9 ~ 12 months

Elasticity modulus : 50-80

Particle Size : 350μm

Fine is less hard and has a smaller particle size. Effectively improves very thinsuperficial lines. Injected in the upper part of the dermis.

Application area : Face, neck, neckline area, back of the hand, fine wrinkles,marionette wrinkles, wrinkles around the mouth, nasolacrimal furrows, horizontalwrinkles on the forehead, forehead wrinkles.

Lasting : 6 ~ 9 months

Elasticity modulus : 30-50

Particle Size : 200μm

ReMedium HA Filler Types
Hyaluronic Acid Gel 50cc

ReMedium 50 

Body Filler contains ZERO impurities.
This is a 100% pure product with hyaluronic acid, which is very easy to use and manufactured with
modern technology. Thanks to this patients could achieve the desired results.

ReMedium 50

Body is a filler with a large capacity of 50 ml, which can be used for the whole body,
but specifically for hips, buttocks, breasts, elbows, knees, calves, male and female intimate areas.

ReMedium 50

Body is an optimal body filler made in Korea that provides enlargement of desired body parts,
improves skin elasticity and maintains volume for a long time using formation of a three-dimensional contour.

ReMedium 50 

Body filler that perfectly structures the body, has high elasticity and strong adhesive force,
which allows to achieve excellent results, incomparable with competitive brands.

Thanks to the Monophasic method and high particle density,
our filler creates perfect volume and elasticity in the skin.

Forms a natural shape and has a long-lasting effect.

Gives you a NATURAL effect and is very easy to use.

Contains 24 mg/cc Hyaluronic Acid, which is significantly
more than other fillers. Safe and contains no impurities.
ReMedium 50 HA
Body Filler
Other body filler
Cross-linking rate
Hyaluronic Acid
Compared to other fillers, Remedium 50 Body contains more Hyaluronic Acid, and it also has high cohesion and high adhesion to skin tissues.
of Lasting
18~24 months
6~12 months
Needle gauge for
removing filler from vial
The concentration of Hyaluronic Acid in the ReMedium 50 BODY filler is 24mg/cc, which is significantly higher than in other fillers.
Needle gauge for
filler injection
And you can determine the excellent viscosity of our filler due to the fact that it cannot be injected with a needle with larger than 186.
Method of drawing filler out of the vial

After removing the aluminum cap and
rubber stopper, insert a 10 ml syringe into the vial.

Turn the vial upside down and begin to
remove the filler with a syringe.

Usually other fillers are more liquid, so you can extract them with a 21 gauge needle.
But not the ReMedium 50 Body filler
since the consistency of our filler is viscous,
which allows it to form three-dimensional contours for you!

  • The highly purified viscoelastic body filler REMEDIUM BODY 50 Filler is the best solution for replenishing body volume and professional body contouring. REMEDIUM BODY 50 restores volume to the body in areas like breasts, lower legs, and buttocks. It is also efficient in combating cellulite and uneven skin surface due to liposuction procedures.
  • Compared to other fillers, ReMedium 50 BODY contains more Hyaluronic Acid, and it also has high cohesion and high adhesion to skin tissues.
  • The concentration of Hyaluronic Acid in the ReMedium 50 BODY filler is 24mg/cc, which is significantly higher than in other fillers. And you can determine the excellent viscosity of our filler due to the fact that it cannot be injected with a needle with larger than 18G.

Low Control Cross-linking Process Technology maximize the viscosity of the cross-linked HA by applying the 3 step nano meshing process
ReMedium 50 uses high purity, non-animal polymeric hyaluronic acid and provides safety and long-lasting effect which minimize

swelling after treatment and help maintain the appearance of the procedure

Product Composition

  • The package contains: 1 vial x 50 ml
  • Cross-linking rate: 10%
  • Hyaluronic Acid Concentration: 24mg/cc
  • Duration of Lasting: 18~24 months
  • Syringe to remove the filler from the vial: 10 ml syringe
  • Needle gauge for removing filler from vial: 18G
  • Needle gauge for filler injection: 16G~18G
  • Fast and easy procedure
  • Delivering safe and effective results
  • Resume daily activities right after the procedure


  • Contains highly purified stabilized hyaluronic acid
  • Has higher viscosity that prevents deformation
  • Small HA particles enable easy modelling of the desired shape
  • Smooths the skin and combats cellulite
  • Suitable for patients, who are not intended to go through surgery, but desire to enlarge volume in areas like breasts and buttocks
  • The hyaluronic acid gel does not contain animal components, eliminating the risk of allergic reactions
  • General anaesthesia is not required
  • No incisions or scars
  • Quick recovery period (compared with plastic surgery)
Sodium Hyaluronate - Sterile Pre-filled

The Aquashine procedure is one of the ways to rejuvenate the skin with the help of a uniform and direct injection of hyaluronic
acid into the dermis layer, which leads to the brightness and moistening of the skin, concentrating the moisture, since the HA has a moistening effect.

Sterile gel preparation based on unstabilized hyaluronic acid “Shiseido” in the
concentration of 10mg/ml, it is injected as Mesotherapy.

ReMedium Aqua injection can help plump up the skin, protect them from the harmful effects of free radicals, improve blood microculation, and normalize the complexion.

Area of use : Forehead, Eyebrows, around eyes, nasolabial wrinkles, chin and breast, hand back, neck and neckline, all face

Effect of the Procedure


Enhance skin radiance
Refine skin texture
Improve skin elasticity
Tighten facial ,neck skin
Address pigmentation concerns (freckles, spots)
Addition to makeup


Removal of fine wrinkles
Enhancing skin elasticity
Preventing skin aging


Enhance skin condition irrespective of seasonal changes
Eliminate dead skin cells


Effect appears after 1-2 weeks
During 3-4 months
Injection Technique

The Drug is injected at a depth of 1mm into the surface layers of the epidermis. The skin should be anesthetized, then ReMedium Aqua should be injected with a needle or an injection device evenly, if necessary other care products also can be applied. Avoid touching, massage, sauna and extreme workout and sunlight.

Lasting and Appeared Effect

– Appeared effect is visible after 1-2 weeks
– Product’s effect lasts for 3-4 months.

Injection Interval

1 st Stage: Inject first 2 treatments by every 3-4 weeks

2 nd Stage: Inject every 3 months after 1st stage

Packaging Info

– Non Cross-linked Hyaluronic acid 20mg/ml
– ReMedium Aqua 2ea x 2ml
– 2 prefilled syringe / 1 box
– The Product is 4 ml in total


The Product increases long-lasting effect in the human body, increases fullness and projection of our breasts and upper buttocks and improves the balance of our figure. The product has strong viscosity, gel hardness and easy molding characteristics. High viscosity is obtained through patented stage micro beads manufacturing technology based on cross linked Hyaluronic Acid.

An elaborate product with high viscosity and cohesiveness through its high cross-linking rate, and a very low particle size to provide moldability, longevity and shape maintenance after the procedure. The product is safe with no chemical modifications in the HA, even after a high cross-linking process.

Upper Breast Side
Increases fullness and projection of Breast and impoves the balance of the figure.

Upper Buttocks Side
Increases fullness and projection of Upper Buttocks and impoves the balance of
the figure.


Results of measuring the sliding down of ReMedium products compared with other brands’ products. After 4 minutes elapse as shown below,
white third-party products slammed down a lot, OUR PRODUCTS CAN BE SEEN TO KEEP SHAPES ON AN ONGOING BASIS.

PDO suture therapy effects

It has qualified clinically to wound closure, can lift up skin tissue and regenerate the skin. improves skin tone and minimizing pores, has strong effect on making a face contouring, arranging protruding area and lifting for sagging area.

Area of Use

Around cheeks, forehead (eyebrow lifting), jawline, sunken cheeks, crow’s feet, neck, nasolabial fold, marionette line

Regarding Lasting

The suture is absorbing within 6-8 months, whose effect lasts for 3 years

ReMedium Vline Types


Injection Procedure

Inject local anesthesia and insert PDO Suture with the needle (cannula). This
Procedure by PDO depends on requirements of clients. It takes 45-60 minutes. Patient can cantinue daily life after treatment.

ReMedium PDRN
Protocol of ReMedium PDRN Application

5 Point Technique Dosage and Protocol


Point highest point in the zygomatic bone


Point of intersection of the midpupillary line  and the line coming from the wing of the nose


Point in the ear tragus


Point of the mental area (chin)


Point in the region of the lower jaw (exit of nerve bundles)


Syringe 2ml
Technique of 5 points each side of the face 1 ml
One injection point 0.2 ml
Inject drug to the subdermal layer of the skin


Syringe 2ml
Technique 10 points to all neck area
Each injection point 0.2 ml
Inject drug to the preplatysmal fat


LipoReM is an injection treatment that naturally dissolves fat, which is not easily removed only through exercising or going on diet. The fat dissolving solution is  injected on subcutaneous fat of face or body to immediately dissolve accumulated fat. Unlike the other fat dissolving ample, it is excellent for dissolving fat and huge effect can be expected after treatment that it brings greater impact for those who did not see any satisfying results with other fat dissolving injection or liposuction.

Ingredients – Camellia Sinensis Leaf Extract,Panax Ginseng Root Extract,Disodium Phosphate,Sodium Phosphate,Sodium Bicarbonate,Collagen,Vitamin B2,Sodium Chloride

Usage Guide

TYPE: Liquid
VOLUME: 10ml x 5 vials
STORAGE : Room temperature
EXPIRY DATE: 2 years

Treatment Guide

LipoReM is a solution that involves fat cells existing under the inner skin that it should be injected deeper than 2mm under inner skin, with variations by  individuals. After treatment, you can immediately return to everyday life as there will be no swelling or bruise but just absolute effect of slim line.

INJECTION POINT: 1~1.5cm interval

INJECTION VOLUME PER POINT: Face : 0.05~0.1ml, Body : 0.1~0.3ml

QUICK TREATMENT: Treatment takes only 5~10 minutes.

LESS PAIN: As an injection treatment, there is almost no pain.

INJECT AREA: Fat layer on Chin, Abdomen, Love handles, Upper arms, Thigh

EFFiCACY: 7-30 days

ADVANTAGE: Volume reduction is fast, No side effects, Immediately life is
available, Simple therapy

  • Avoid stimulation, make-up or cleansing on treatment area for 6 hours after treatment and gently cleanse on the day of treatment.
  • Effect of treatment will appear within 1 week after treatment.
  • Occasionally, people with large or thick layer of fat may experience slower effect within about 1 or 2 weeks.
  • It is recommended to avoid intense sports, sauna, drinking and smoking for about 1 week after treatment (Alcohol may interrupt breakdown of fat that the effect of treatment may be insignificant or none).
  • Depending on physical constitution, allergic reactions may occur.
  • Prescribed antibiotic medicines help reducing swelling and allergic reactions and are recommended to take.
Treatment Guide

Face is divided into half for treatment, normally on anterior or below cheek. Design points at intervals of approximately 1.5cm on treatment area and inject. 0.05~0.1ml on each point. Needle Gauge: 29~30g; Cannula Gauge: 25~26g


The amount of injection is 0.15ml~0.2ml per each point, where there are total 20 points including 10 points on each upper and bottom part of forearm. Apply the same on the other side of forearm. You will use 4~5ml of medicine for one side of forearm that total of 8~10mL will be used.


The injection should be injected on inner part and bottom part of thigh. However, as the area of treatment is wider than that of forearm, LipoReM should be injected on 3-40 points on inner and bottom part of thigh with 0.15ml~0.25ml on each point. The other side of thigh should be treated the same and, on each thigh 6ml of injection will be used.


Injection amount is 0.25~0.3ml per point. Centering the belly button, injection areas should be 20 points above, 15 points on both sides and 15 points on both sides of flank. According to patient condition, the point areas for injection can be adjusted. The total medicine used will be 20ml.


Treatment area is right on top of the underline of hip(banana line). The first point of injection is the banana line nearest to anus and keep injecting with interval of 2.0~2.5cm until the end of banana line. Inject on the other side of butt the same way. Approximately 10~15 points will be injected on each side of butt and total of 5ml of medicine will be used while there can be variation by individuals.


Normally, 29~31 gage and 25mm insulin syringe are filled for usage. It is recommended to treat for 2~3 times with 1 month interval. It is not recommended to inject more than 0.3ml on the same point. Injection should be made to fat layer, and based on the folding line under the lower jaw, inject on the line of oval with 1.5~2.0cm of interval between points while adjusting the volume of injection.

Warnings and specific precautions
regarding application
Side Effects That Can Occur At The Result Of The Filler Application

– Redness, pain, tenderness

– Swelling, bruising, itching, infection

– Allergic reactions, discharge swelling, sunkenscar

– Palpable masses, asymmetry, color change feltwhile touching

– Blood circulatory disorders (ischemia) as a resultof constriction of blood vessels or blockage byfiller particles

– Skin necrosis

– Unilateral, bilateral visual impairment or blindness

Side Effects That Can Occur At The Result Of The Filler Application

– Before coming to the filler application procedure, please come well rested(relaxed) and haled.

– Do not consume alcoholic beverages before the application.

– It is not recommended to take blood thinners (aspirin, etc.), high-dose vitamin E, anti-rheumaticnon-steroidal anti-inflammatory drugs, retenoids and hormonal drugs at least two weeks prior tothe filler application procedure.

Rehabilitation period

– Do not touch the filler applied area

– Make-up can be applied at least after 24 hours

– It is advied to avoid intense sports for at least 2 weeks

– Avoid hot environments such as saunas and jacuzzis for at least 2 weeks

– In case of lip augmentation, do not consume hot-cold food and drinks for 3 days

– Do not eat or drink anything until the sensation returns (2-3 hours) as the while lip augmentations the lipis anesthetized

– Do not massage the application area for at least 1 week.

– Bruising caused by injection usually lasts 4-10 days, swelling lasts 3-7 days.

– The settling time of the filler in the filler application area is 2-4 weeks. It is normal to have asymmetryand unevenness during this period.

– In case of any contraindications not mentioned above, please consult your treating physician.

Frequently Asked Question

For more questions, mail us at [email protected]

Derma Fillers are made from a substance that occurs  naturally in human skin-this means they are extremely safe to use and can give fantastic enhancements to lips and facial lines.

You will see results immediately, however, some swelling and redness is not uncommon and as such, the immedicate result should not be regarded as the final result. Best results are seen after 2-3 days

It is long lasting, but not permanent. Depending on the product used, the injection area treated and the individual dispozitions of your skin, the results can last from 6 months up to 18 months.

You may experience some discomfort such as temporary tenderness, redness, swelling on the injected area. They usually disappear on their own in less than 7 days. You can apply an ice pack for a brief period on the injection site to help ease any swelling.

The injections are done with very fine needles and are usually pain-free. Subject to the treated area and your sensitivity, anesthetic cream or block can be applied before the procedure.

In order to reduce the risk of bruising and bleeding at the injection site, avoid any medications such as anticoagulants and  antiinflammatories, that can
prolong bleeding, the week before receiving the treatment. After the injection, you should not apply any make-up for 12 hours and avoid sunbathing or high temperatures for one week. Ask your healthcare professional what he or she recommends.